Mutagenic effects of unsymmetrical dimethylhydrazine and n-nitrosodimethylamine on mammals

Authors

  • S. Zh. Kolumbayeva Казахский национальный университет им. аль-Фараби
  • A. V. Lovinskaya Казахский национальный университет им. аль-Фараби
  • D. A. Begimbetova Nazarbayev University image/svg+xml
  • A. M. Kalimagambetov Казахский национальный университет им. аль-Фараби
  • В. В. Zhunusbekova Казахский национальный университет им. аль-Фараби

Keywords:

unsymmetrical dimethyl, N-nitrosodimethylamine, aberrations, DNA – comet method.

Abstract

The article represents the application of cytogenetic and Comet assay for studying mutagenic effects of unsymmetrical dimethylhydrazine and N-Nitrosodimethylamine. The statistical analysis revealed a dosedependent and time-dependent (acute, subacute study) genotoxic activity of these xenobiotics on mice. Statistically significant increases of cells with aberrant metaphases and level of polyploid cells were observed. Organ-specific genotoxicity of UDMH and NDMA is established. The mice organs may be arranged by sensitivity to DNA damaging action as follows: lungs

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Published

2016-01-14

Issue

Vol. 38 No. 2/2 (2013): Вестник Каз НУ Серия Экологическая

Section

ENVIRONMENTAL IMPACT OF ANTHROPOGENIC FACTORS AND ENVIRONMENTAL PROTECTION

How to Cite

Mutagenic effects of unsymmetrical dimethylhydrazine and n-nitrosodimethylamine on mammals. (2016). Eurasian Journal of Ecology, 38(2/2). https://bulletin-ecology.kaznu.kz/index.php/1-eco/article/view/300