The study of spasmolytic activity, acute and chronic toxicity of piperidine derivative – NA-323 substance

Authors

  • B. Baibolsynova РГП «Центральная лаборатория биоконтроля, сертификации и предклинических испытаний» КН МОН РК
  • I. S. Kolbay АО «Международный университет информационных технологий»
  • A. T. Kanaev Казахский национальный педагогический университет им. Абая
  • A. T. Orazova РГП «Центральная лаборатория биоконтроля, сертификации и предклинических испытаний» КН МОН РК

Keywords:

mice, rats, experiment, spasmolytic activity, acute and chronic toxicity.

Abstract

In experiments on rats and mice the spasmolytic activity, acute and chronic toxicity of including complex of oxalate 1-(2-etoxietil)-4-(hexine-1-il)-4-propionil-oxipiperidine derivate – NA-323 substance were investigated. It was established the pronounced spasmolytic activity of this substance, which is expressed in suppression of acetylcholineinduced tonic contraction of a gut segment. In experiments it was shown an absence of acut and chronic toxicity of NA-323 substance in the dozes of 1,0,10,0 и 50 mg/kg

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Published

2016-01-14

Issue

Vol. 40 No. 1/2 (2014): Вестник Каз НУ Серия Экологическая

Section

ENVIRONMENTAL IMPACT OF ANTHROPOGENIC FACTORS AND ENVIRONMENTAL PROTECTION

How to Cite

The study of spasmolytic activity, acute and chronic toxicity of piperidine derivative – NA-323 substance. (2016). Eurasian Journal of Ecology, 40(1/2). https://bulletin-ecology.kaznu.kz/index.php/1-eco/article/view/602