Changes in the antioxidant defence system of the rat subjected to combined effect of crude oil and vanadium
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Ключевые слова:
crude oil, vanadium,Аннотация
Аммоний метаванадатын (AMV, 0,30 мг/мл) және / немесе шикі мұнай (СО, денесінің массасына шаққанда, 0,5 мл/кг) 21 күн қабылдаған еркек егеуқұйрықтарда мыналар зерттелді: трансаминдеу ферменттері – аланинаминотрансферазаның (АЛТ), аспартатаминотрансферазаның (АСТ) белсенділіктері және супероксиддисмутазаның (СОД), глутаион-S-трансферазаның (GST) антиоксидантты қорғаныштық белсенділіктері және глутатион (GSH) мөлшері. Ванадий тұзының (AMV) және / немесе шикі мұнайдың (СО) ұзақ уақыт әсері қан сарысуындағы аминотрансферазалар (АЛТ және АСТ) индукциясының айтарлықтай төмендеуіне (р < 0,001), ал бауыр мен бүйректе ПОЛ белсенділігінің жоғарылауына алып келді. Сонымен қатар супероксиддисмутаза (СОД) белсенділігінің төмендейтіндігі (р < 0,001) және глутатион (GSH) мөлшерінің азаятындығы байқалды. AMV және AMV-СО-мен әсер еткенде егеуқұйрықтың бауыры мен бүйрегінде глутаион-S-трансферазаның (GST) белсенділігі айтарлықтай төмендейді (р < 0,001), ал СО-мен әсер еткенде глутаион-S- трансферазаның (GST) белсенділігі бауырда едәуір индукцияланады (р < 0,01), бірақ та оның белсенділігі, бақылаудағы жануарлармен салыстырғанда, бүйректе өзгермейді. Ванадий тұзын қабылдаған жануарлардың барлығында улану белгісі байқалды, жануарлар салмағының төмендеуі және өлім жиілігінің жоғарылауы осының дәлелі болып табылады. Алынған нәтижелер AMV және / немесе СО-индуцирленген тотығу стресінің әсеріне, бүйрекпен салыстырғанда, бауырдың осалдау болатындығы, сонымен бірге AMV және СО-ның біріккен тотықтырғыштық стрестік әсері, олардың әрқайсысының жекелеген әсерімен салыстырғанда, айқынырақ көрінедіБиблиографические ссылки
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8 Zaporowska H. Effect of vanadium on L-ascorbic acid concentration in rat tissues // Gen Pharmacol. - 1994. - No 25. – Р. 467-470.
9 Khan AA, Coppock RW, Schuler MM, Geleta L. Biochemical changes as early stage systemic biomarkers of petroleum hydrocarbon exposure in rats // Toxicol Lett. - 2002. - No 134. – Р. 195-200.
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13 Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation // J. Biol.Chem. - 1974. - No 249. – Р.7130–7139.
14 Landu S, Everitt BS. A handbook of statistical Analyses using SPSS. – London: Chapman and Hall/CRC press LLC, 2004. - 337 p.
15 Thompson KH, McNeill JH. Effect of vanadyl sulfate feeding on susceptibility to peroxidative change in diabetic rats // Res Commun Chem Pathol Pharmacol. - 1993. - No 80. – Р.187-200.
16 Timbrell JA. Principles of Biochemical Toxicology, – London: Taylor and Francis, 1991. – 563 р.
17 Scibior A, Zaporowska H. Effects of combined vanadate and magnesium treatment on erythrocyte antioxidant defence system in rats // Environ Toxicol Pharmacol. - 2010. - No 30. Р. 153-161.
18 Byczkowski JZ, Channel SR. chemically induced oxidative stress and tumorigenesis: effects on signal transduction and cell proliferation // Toxic Subst. Mechan. - 1996. - No 15. – Р. 101-128.
T.M. Shalakhmetova, B.A. Umbayev,K.E. Mahmoud115ISSN
1563-034Х KazNU Bulletin. Ecology series. No2 (34).2012
19 Younes M, Kayser E, Strubelt O. Effect of antioxidants on vanadate-induced toxicity towards isolated perfused rat livers // Toxicology. - 199. - No 70. – Р. 141–149.
20 Russanov E, Zaporowska H, Ivancheva E, Kirkova M, Konstantinova S. Lipid peroxidation and antioxidant enzymes in vanadate-treated rats // Comp Biochem Physiol Pharmacol Toxicol Endocrinol. - 1994. - No 107. – Р. 415- 421.
21 Khan AA, Coppock RW, Schuler MM. Effects of multiple exposures of small doses of Pembina Cardium crude oil and diesel in rats // Arch Environ Contam Toxicol. - 2001. - No 40. – Р. 418-424.
22 Halliwell B. Reactive oxygen species and the central nervous system // J Neurochem. - 1992. - No 59. – Р. 1609-1623.
23 Liu J, Mori A. Involvement of reactive oxygen species in emotional stress: A hypothesis based on the immobilization stress-induced oxidative damage and antioxidant defense changes in rat brain, and the effect of antioxidant treatment with reduced
glutathione // Int. J. Stress Mgt. - 1994. - No 1. – Р. 249 – 263.
24 Soussi A, Croute F, Soleilhavoup JP, Kammoun A, El-Feki A. Impact of green tea on oxidative stress induced by ammonium metavanadate exposure in male rats // C R Biol. - 2006. - No 329.
– Р. 775-784.
25 Chandra AK, Ghosh R, Chatterjee A, Sarkar M. Effects of vanadate on male rat reproductive tract histology, oxidative stress markers and androgenic enzyme activities // J. Inorg. Biochem. - 2007. - No 101. – Р. 944–956.
26 Mates JM, Perez-Gomez C, Núñez de Castro I. Antioxidant enzymes and human diseases // Clin. Biochem. - 1999. - No 32. – Р. 595-603.
27 Arrigo AP. Gene expression and the thiol redox state. //Free Radic Biol Med. - 1999. - No 27. – Р. 936-44.
28 Uyanık F, Eren M, Atasever A, Tunçoku G, Kolsuz AH. Changes in Some Biochemical Parameters and Organs of Broilers Exposed To Cadmium and Effect of Zinc on Cadmium Induced Alterations // Israel J. Vet. Med. - 2001. - No 56. – Р. 128-134.
29 Chiapotto e, Biasi f, Scavazza A, Camandola S, Aragno M, Tamagno E, Danni O, Dianzan MU, Poli G. Acetaldehyde involvement in ethanol induced potentiation of rats hepatocyte damage due to
the carcinogen 1, 2 – dibromoethanol // Alcohol and Alcoholism. - 1995. - No 30. – Р. 721-728
2 Kalogeropoulos N, Scoullos M, Vassilaki-Grimani M, Grimanis AP. Vanadium in particles and sediments of the northern Saronikos Gulf, Greece // Sci Total Environ. - 1989. - No 79. – Р. 241-252.
3 Vazquez F, Sanchez M, Alexander H, Delgado D. Distribution of Ni, V, and petroleum hydrocarbons in recent sediments from the Veracruz coast, Mexico // Bull Environ Contam Toxicol. - 1991. - No 46. – Р.774 -781.
4 Zychlinski L. Toxicological appraisal of work-places exposed to the dust containing vanadium pentoxide // Bromat. Chem. Toksykol (Pol.). - 1980. - No 8. – Р. 195-199.
5 Flyger H, Jensen FP, Kemp K. Air pollution in copenhagen. Part I. Element analysis and size distribution of aerosols // RISO Rep. Mar. - 1976. - No 338. – Р. 1-70.
6 Stohs SJ, Bagchi D. Oxidative mechanisms in the toxicity of metal ions // Free Radic Biol Med. - 1995. - No 18. – Р. 321-336.
7 Chen F, Ding M, Castranova V, Shi X. Carcinogenic metals and NF-kappa B activation // Mol Cell Biochem. - 2001. - No 222. – Р. 159-171.
8 Zaporowska H. Effect of vanadium on L-ascorbic acid concentration in rat tissues // Gen Pharmacol. - 1994. - No 25. – Р. 467-470.
9 Khan AA, Coppock RW, Schuler MM, Geleta L. Biochemical changes as early stage systemic biomarkers of petroleum hydrocarbon exposure in rats // Toxicol Lett. - 2002. - No 134. – Р. 195-200.
10 Burlakova EB, Аlesenko AV, Molochkina EM, Palmina NP, Khrapova NG. Bioantioxidants for radiation damage and malignant growth. – Moscow.: Nauka, 1975. - 214 p.
11 Baker MA, Cerniglia GJ, Zaman A. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples // Anal. Biochem. - 1990. - No 190. – Р. 360 – 365.
12 Marklund S. Distribution of CuZn superoxide dismutase and Mn superoxide dismutase in human tissues and extracellular fluids // Acta Physiol. Scand. Suppl. - 1980. - No 492. Р. 19 – 23.
13 Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation // J. Biol.Chem. - 1974. - No 249. – Р.7130–7139.
14 Landu S, Everitt BS. A handbook of statistical Analyses using SPSS. – London: Chapman and Hall/CRC press LLC, 2004. - 337 p.
15 Thompson KH, McNeill JH. Effect of vanadyl sulfate feeding on susceptibility to peroxidative change in diabetic rats // Res Commun Chem Pathol Pharmacol. - 1993. - No 80. – Р.187-200.
16 Timbrell JA. Principles of Biochemical Toxicology, – London: Taylor and Francis, 1991. – 563 р.
17 Scibior A, Zaporowska H. Effects of combined vanadate and magnesium treatment on erythrocyte antioxidant defence system in rats // Environ Toxicol Pharmacol. - 2010. - No 30. Р. 153-161.
18 Byczkowski JZ, Channel SR. chemically induced oxidative stress and tumorigenesis: effects on signal transduction and cell proliferation // Toxic Subst. Mechan. - 1996. - No 15. – Р. 101-128.
T.M. Shalakhmetova, B.A. Umbayev,K.E. Mahmoud115ISSN
1563-034Х KazNU Bulletin. Ecology series. No2 (34).2012
19 Younes M, Kayser E, Strubelt O. Effect of antioxidants on vanadate-induced toxicity towards isolated perfused rat livers // Toxicology. - 199. - No 70. – Р. 141–149.
20 Russanov E, Zaporowska H, Ivancheva E, Kirkova M, Konstantinova S. Lipid peroxidation and antioxidant enzymes in vanadate-treated rats // Comp Biochem Physiol Pharmacol Toxicol Endocrinol. - 1994. - No 107. – Р. 415- 421.
21 Khan AA, Coppock RW, Schuler MM. Effects of multiple exposures of small doses of Pembina Cardium crude oil and diesel in rats // Arch Environ Contam Toxicol. - 2001. - No 40. – Р. 418-424.
22 Halliwell B. Reactive oxygen species and the central nervous system // J Neurochem. - 1992. - No 59. – Р. 1609-1623.
23 Liu J, Mori A. Involvement of reactive oxygen species in emotional stress: A hypothesis based on the immobilization stress-induced oxidative damage and antioxidant defense changes in rat brain, and the effect of antioxidant treatment with reduced
glutathione // Int. J. Stress Mgt. - 1994. - No 1. – Р. 249 – 263.
24 Soussi A, Croute F, Soleilhavoup JP, Kammoun A, El-Feki A. Impact of green tea on oxidative stress induced by ammonium metavanadate exposure in male rats // C R Biol. - 2006. - No 329.
– Р. 775-784.
25 Chandra AK, Ghosh R, Chatterjee A, Sarkar M. Effects of vanadate on male rat reproductive tract histology, oxidative stress markers and androgenic enzyme activities // J. Inorg. Biochem. - 2007. - No 101. – Р. 944–956.
26 Mates JM, Perez-Gomez C, Núñez de Castro I. Antioxidant enzymes and human diseases // Clin. Biochem. - 1999. - No 32. – Р. 595-603.
27 Arrigo AP. Gene expression and the thiol redox state. //Free Radic Biol Med. - 1999. - No 27. – Р. 936-44.
28 Uyanık F, Eren M, Atasever A, Tunçoku G, Kolsuz AH. Changes in Some Biochemical Parameters and Organs of Broilers Exposed To Cadmium and Effect of Zinc on Cadmium Induced Alterations // Israel J. Vet. Med. - 2001. - No 56. – Р. 128-134.
29 Chiapotto e, Biasi f, Scavazza A, Camandola S, Aragno M, Tamagno E, Danni O, Dianzan MU, Poli G. Acetaldehyde involvement in ethanol induced potentiation of rats hepatocyte damage due to
the carcinogen 1, 2 – dibromoethanol // Alcohol and Alcoholism. - 1995. - No 30. – Р. 721-728
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Как цитировать
Shalakhmetova, T. M., Umbayev, B. A., & Mahmoud, K. E. (2016). Changes in the antioxidant defence system of the rat subjected to combined effect of crude oil and vanadium. Вестник КазНУ. Серия Экологическая, 34(2). извлечено от https://bulletin-ecology.kaznu.kz/index.php/1-eco/article/view/474
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ОЦЕНКА ДЕЙСТВИЯ ЗАГРЯЗНИТЕЛЕЙ ОКРУЖАЮЩЕЙ СРЕДЫ НА БИОТУ И ЗДОРОВЬЕ НАСЕЛЕНИЯ
