GENETIC ANALYSIS OF NUCLEOPROTEIN OF A/H3N8 INFLUENZA VIRUS OF ASIAN AND EUROPEAN ORIGIN ISOLATED IN 2018
DOI:
https://doi.org/10.26577/EJE.2024.v80.i3-010Abstract
This paper presents the results of a genetic analysis of the nucleoprotein gene (NP) of two strains of avian influenza virus isolated in the territory of the Republic of Kazakhstan in 2018 near small lakes (Alua and Zaimishche) of the North Kazakhstan region. These strains showed the presence of 54 in the nucleotide and 4 substitutions in the amino acid sequence, thereby significantly distancing themselves from each other. In phylogenetic analysis, the strain A/northern shoveler/North-Kazakhstan/20/2018(H3N8) showed the greatest relationship with strains from Europe, the homology between strains showed 96-97%. The second strain A/garganey/North Kazakhstan/45/2018(H3N8) showed genetic similarity with strains from Asia, the NP gene identity was 99%.
Keywords: influenza, virus, NP, avian IAV, H3N8, vRNP, RNA