Biochemical changes in male albino rats following single exposur e to crude oil and ciprofloxacinCrude oil, Ciprofloxacin
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Keywords:
Crude oil, Ciprofloxacin,Abstract
Биохимиялық әдістердің көмегімен еркек егеуқұйрықтарда шикі мұнайдың (СО 3,0 мл / кг) және ципрофлоксациннің (CFХ, 200 мг / кг) бір рет әсер еткендегі гепатотоксикалық әсері зерттелді. Шикі мұнаймен әсер еткенде жануарлардың бауырындағы Р-450 цитохромы мөлшерінің, бақылаумен салыстырғанда, 1 күннен кейін 4,0 есе, ал 2 күннен кейін 7,6 есе жоғарылайтындығы, ал содан кейін алғашқы күнгі деңгейге дейін түсетіндігі анықталды. CFХ Р-450 белсенділігін едәуір тежейді, ал шикі мұнай мен CFХ әсері фермент белсенділігін индукциялайды, бірақ ол екеуінің біріккен әсері, шикі мұнайдың жеке әсерімен салыстырғанда, төмендеу болады. Р-450 цитохромы белсенділігінің тежелуі липидтердің (ПОЛ) тотығу процестеріне әсер етпейді, ал организмнен тежегіштерді алып тастаған кезде олардың белсенділігінің жоғарылауына және Р-450 цитохромы белсенділігінің кідіруіне алып келеді. Шикі мұнай және CFХ-тің бір қайтара әсері бауыр клеткаларында деструктивті өзгерістерге әкеледі, нәтижесінде CYР-450-дің ципрофлоксацин көмегімен тежелуі шикі мұнай әсерінен болған липидтердің асқын тотығуынан қорғай алмайды.References
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in rat brain and the effect of antioxidant treatment with reduced glutathione // Int J Stress Mgt. 1994. - No 1. – Р. 249-263.
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27 Weyers A, Ugnia LI, Ovando HG and Gorla NB. Antioxidant capacity of vitamin C in mouse liver and kidney tissues // Biocell. - 2008. - No 32. – Р. 27-31.
2 Месторождения нефти и газа Казахстана: справочник. – Алматы, 2007. – 316 с.
3 Белов П.С. Экология производства химических продуктов из углеводородов нефти и газа.- М., 1991. – 376 с.
4 Miklosovicova L. and Trzilova B. Biodegradation of crude oil hydrocarbons in water environment // Biologia. - Bratislava, 1991. - No46. – Р. 219 – 228.
5 Albers PH. Petroleum and individual polycyclic aromatic hydrocarbons // In Handbook of Ecotoxicology / Hoffman, D.J., Rattner, B.A., Burton, G.A., and J. Cairns. (eds.). - Florida: Lewis Pub
lishers, Boca Raton, 1995. - Chapter 15. – p. 330 – 355. T.M. Shalakhmetova, K.E. Mahmoud,B.A. Umbayev107 ISSN 1563-034Х KazNU Bulletin. Ecology series. No2 (34). 2012
6 National Research Council. Oil in the Sea: Inputs, Fates, and Effects. – Washington.: National Academy Press, DC, USA, 1985. - p. 7–10.
7 Occupational Exposures in Petroleum Refining; Crude Oil and Major Petroleum Fuels: мonographs. - International Agency for Research on Cancer (IARC), 1989. – 120 р.
8 Mansuy D. The great diversity of reactions catalyzed by cytochromes P450 // Comp Biochem Physiol C Pharmacol Toxicol Endocrinol - 1998. - No 121. – Р. 5-14.
9 Poland A and Knutson JC. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity // Ann Rev Pharmacol
Toxicol. - 1982. - No 22. – Р. 517-554.
10 Schenkman JB and Cinti DL. Preparation of microsomes with calcium // Methods Enzymol. - 1978. - No 52. – Р. 83–89.
11 Omura T. and Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature // J Biol Chem. - 1964. - No 239. –Р. 2370-2378.
12 Guengerich FP. Analysis and characterization of enzymes // In: Principles and methods of toxicology, Hayes A.W (eds). 3rd Edn. - New York: Raven Press, 1994. – Р. 1259—1313.
13 Burlakova EB, Аlesenko AV, Molochkina EM, Palmina NP and Khrapova NG. Bioantioxidants for radiation damage and malignant growth. – М., 1975. - 214 р.
14 Landu S, Everitt BS. A handbook of statistical Analyses using SPSS. – London: Chapman and Hall/CRC press LLC, 2004. – 337 р.
15 Dipple A, Michejda CJ and Weisburger EK. Metabolism of chemical carcinogens // Pharmacol Ther. - 1985. - No 27. – Р. 265-296.
16 Guengerich FP and Liebler DC. Enzymatic activation of chemicals to toxic metabolites // Crit Rev Toxicol. - 1985. - No 14. – Р. 259–307.
17 Lu AY and West SB. Multiplicity of mammalian microsomal cytochromes P-450 // Pharmacol Rev.- 1980. - No 31. – Р. 277-295.
18 Wrighton SA and Stevens JC. The human hepatic cytochromes P450 involved in drug metabolism // Crit Rev Toxicol. - 1992. - No 22. – Р. 1-21.
19 Pyykko K., Paavilainen S, Metsa-Ketela T and Laustiola K. The increasing and decreasing effects of aromatic hydrocarbon solvents on pulmonary and hepatic cytochrome P-450 in the rat // Pharmacol
Toxicol. - 1987. - No 60. – Р. 288-293.
20 Toftgard R, Halpert J, Gustafsson JA. Xylene induces a cytochrome P-450 isozyme in rat liver similar to the major isozyme induced by Phenobarbital // Mol Pharmacol - 1983. - No 23. – Р.
265-271.
21 Khan AA, Coppock RW and Schuler MM. Effects of multiple exposures of small doses of Pembina Cardium crude oil and diesel in rats // Arch Environ Contam Toxicol - 2001. - No 40. Р. 418-424.
22 Downs CA, Shigenaka G, Fauth JE, Robinson CE, and Huang A. Cellular physiological assessment of bivalves after chronic exposure to spilled Exxon Valdez crude oil using a novel molecular diagnostic
biotechnology // Environ Sci Technol. - 2002. - No 36. Р. 2987-2993.
23 Liu J and Mori A. Involvement of reactive oxygen species in emotional stress: a hypothesis based on the immobilizations stress-induced oxidative damage and antioxidant defence changes
in rat brain and the effect of antioxidant treatment with reduced glutathione // Int J Stress Mgt. 1994. - No 1. – Р. 249-263.
24 Machlin LJ and Bendich A. Free radical tissue damage: protective role of antioxidant nutrients // FASEB J. - 1987. - No 1. – Р. 441-446.
25 Sies H. Oxidative stress: Introduction. In: Oxidative Stress: oxidants and Antioxidants. NY.: H. Sies Ed, Academic Press, 1991. – 639 р.
26 Weyers AI, Ugnia LI, García Ovando H and Gorla NB.Ciprofloxacin increases hepatic and renalipid hydroperoxides levels in mice // Biocell. - 2002. - No 26. – Р. 225-228.
27 Weyers A, Ugnia LI, Ovando HG and Gorla NB. Antioxidant capacity of vitamin C in mouse liver and kidney tissues // Biocell. - 2008. - No 32. – Р. 27-31.
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Shalakhmetova, T. M., Mahmoud, K. E., & Umbayev, B. A. (2016). Biochemical changes in male albino rats following single exposur e to crude oil and ciprofloxacinCrude oil, Ciprofloxacin. Eurasian Journal of Ecology, 34(2). Retrieved from https://bulletin-ecology.kaznu.kz/index.php/1-eco/article/view/473
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ASSESSMENT OF THE EFFECTS OF ENVIRONMENTAL POLLUTANTS ON BIOTA AND HEALTH OF THE
