K Kolumbayeva S.Zh., Lovinskaya A.V., Shalakhmetova T.M., Suvorova M.A., Voronova N. The antimutagenic potential of biologically active compounds of Inula britannica L. family Compositae

Al-Farabi Kazakh national university, Almaty, Kazakhstan *Е-mail: S_kolumb@mail.ru

Abstract

Cytogenetic and mutagen-modified effects of biologically active compounds (BAC) of Inula britannica L. extracts from both shoots and roots parts were investigated testing on count chromosome abnormalities of cells of barley root meristem. It was established that plant extracts in concentrations 50.0 and
100.0 mg/l decrease the level of spontaneous mutagenesis in root meristem of barley.
The combined exposure of seeds to methyl methanesulfonate (MMS) and extracts independently
on treatment sequence result in statistically significant reduce of MMS-induced mutagenesis. The data
obtained testify to the presence of antimutagenic effect in studied extracts. There was revealed no differences in gene protective effect of whether aboveground or underground parts of I.britannica despite on
greater content of BAC in underground part.
Key words: Inula britannica, biologically active compound, extract, mutagen, antimutagen, chromosomal aberration.