Baktybayeva L.K., Tauassarova M.K., Berlin Kenneth Darrell, Yu V.K., Zazybin A.G., Malmakova A.E. Myelostimulating activity of pyperidine compounds BIV-68, BIV-69, BIV-70, BIV-71

Kazakh National university, Almaty, Kazakhstan; Oklahoma State University, Center for Health Sciences, Stillwater, Oklahoma City, USA 3Institute of Chemical Sciences named after A. B. Bekturov, Almaty, Kazakhstan; Kazakh-British Technical University, School of Chemical Engineering, Almaty, Kazakhstan

Abstract

The urgency of engineering of new effective myelostimulating drugs substantiated by the growing
percentage of incidence of various diseases hemodepression. One of the factors in the development
of depressive diseases are negative environmental factors. Various kinds of radiation, heavy metals,
petroleum products (solution Shtoddart), trinitrotoluol, pesticides, organochlorine compounds, lindane
(gamma-hexachlorocyclohexane), DDT (dichlorodiphenyltrichloroethane), many drugs have a myelostimulating suppressive effect. Therefore, the search myelostimulating drugs relevant today. In addition,
myelostimulating are widely used in ophthalmology and biotechnology. The newly synthesized azaheterocycles compounds with piperidinium core was investigated on myelostimulating activity on the
cyclophosphamide myelodepressive model. Complex of 3-(3ethoxypropyl)-7-(2-morpholinoethyl)-3,7-
diazabicyclo[3.3.1]nonan with β-cyclodextrin is compound BIV-68. Compound BIV-69 is presented
3-(3-i-propoxypropyl)-7-[2-(1-piperazine)ethyl-)]-3,7-diazabicyclo[3.3.1]nonan as complex of with
β-cyclodextrin. 3,7-Diazabicyclo [3.3.1] nonane-9-one is fairly easily converted to oximes by treatment
with hydroxyamine hydrochloride. Following benzoylation leads to benzoic ester, whose complex with
β-cyclodextrin is BIV-70. Complex of 1- (2-ethoxyethyl)-4-(oct-1-yn-1-yl) piperidin-4-yl propionate with
β-cyclodextrin is compound BIV-71. The compound of the BIV-69 had a high myelostimulating effect
on the proliferation lymphomyeloid pools of blood on the cyclophosphamide myelodepressive model.
By activity compounds BIV-71, BIV-68 and BIV-70 was inferior to the compound of the BIV-69. Thus,
azaheterocycles compounds with piperidinium core are perspective for search of new effective myelostimulating drugs.
Key words: N-alkoxyalkyl piperidines, diazabicyclononanes, benzoyloxime, 14-(oct-1-yn-1-yl)piperidin-4-yl propionate, myelostimulating activity