Lovinskaya A.V., Kolumbayeva S.Zh., Esim Zh.I., Voronova N. The antimutagenic potential of extracts from Limonium gmelinii family Plumbaginaceae (= Limoniaceae Lincz.)

Al-Farabi Kazakh National University, Kazakhstan, Almaty, *e-mail: annalovinska@rambler.ru

  • Lovinskaya A.V. Kolumbayeva S.Zh., Esim Zh.I., Voronova Al-Farabi Kazakh National University,

Аннотация

The cytogenetic and mutagen-modifying activity of a complex of biologically active substances inextracts from shoot and root parts of Limonium gmelinii were investigated testing on count chromosomeabnormalities of cells of barley root meristem. Plant extracts in concentrations 50.0 and 100.0 mg/L haveno mutagenic activity, but, on the contrary, reduced the level of spontaneous mutagenesis. As a resultof the combined effect of methanesulfonate mutagen (MMS) and plant extracts, a statistically significantdecrease in the level of MMS-induced mutagenesis was observed. Extracts of BAS from the shoot androot parts of L. gmelinii in all concentrations and all variant of treatment have strong antimutagenic activity against MMS. The maximum antimutagenic effects were observed during BAS preliminary treatmentMMS exposure and were 64.70% and 67.46% for the root and shoot parts, correspondingly. The mitotic index (MI) of the root meristem of germinating seeds, separately and jointly treated with MMS andextracts, was studied. Plant extracts gave a mitostimulatory effect, while MMS significantly reduced theproliferative activity of the root meristematic cells as compared to the control. Pre- and post- treatmentof BAS from the shoot and root parts statistically significantly increased the mitotic activity of the rootmeristem in comparison with MMS. Genoprotective action of these BASs can be due to their ability toinhibit free radical processes, enhanced by the action of various genotoxicants, and to stimulate chromosome repair. Herbal preparations can be considered the most promising as therapeutic agents aimed atleveling the action of mutagens on the body.Key words: Limonium gmelinii, biologically active substances, antimutagen, chromosome aberrations, mitotic index.
Как цитировать
KOLUMBAYEVA S.ZH., ESIM ZH.I., VORONOVA, Lovinskaya A.V.. Lovinskaya A.V., Kolumbayeva S.Zh., Esim Zh.I., Voronova N. The antimutagenic potential of extracts from Limonium gmelinii family Plumbaginaceae (= Limoniaceae Lincz.). Вестник КазНУ. Серия экологическая, [S.l.], v. 52, n. 3, p. 36-44, apr. 2018. ISSN 2617-7358. Доступно на: <https://bulletin-ecology.kaznu.kz/index.php/1-eco/article/view/777>. Дата доступа: 11 aug. 2022
Раздел
ВОЗДЕЙСТВИЕ НА ОКРУЖАЮЩУЮ СРЕДУ АНТРОПОГЕННЫХ ФАКТОРОВ И ЗАЩИТА ОКРУЖАЮЩЕЙ СРЕДЫ