Esеmсiitova Z.B., Sinyavsky Yu.A., Umutbaeva G.B., Yakunin A.V. The Influence of Hypokinesia on the Status of the Antioxidant defense System in Blood and Tissues of Rats

1Al-Farabi Kazakh National university, Kazakhstan, Almaty 2Kazakh Academy of Nutrition, Kazakhstan, Almaty

Abstract

_{The results of biochemical studies of the effect of hypokinetic stress
on the state of antioxidant defense system in the blood and liver of rats,
as well as the correction of the effects of antioxidant substances hypokinesia nature – alpha-tocopherol, and resveratrol. Assessing the impact
of hypokinesia on the state of the antioxidant status of the animals was
carried out on white rats weighing 250 ± 50g. The serum and liver were
evaluated postmitochondrial supernatant protein, superoxide dismutase
activity (SOD) and catalase, the level of final and intermediate products of
lipid peroxidation and total antioxidant activity. Evaluation of primary lipid
peroxidation products (diene conjugates), the secondary lipid peroxidation
products (malondialdehyde) and the end of lipid peroxidation products
(Schiff base) testified to improve their level in the dynamics of 15 and 30
days of hypokinesia, marked decrease in activity of antioxidant enzymes.
The additional intake of resveratrol and alpha-tocopherol favorable impact
on the state of the antioxidant system, which was manifested in a significant decrease in serum and liver of rats lipid peroxidation products and
increasing the total antioxidant activity.
Key words: antioxidant protection, alpha tokofrol, hypokinesia, human ecology, lipid peroxidation, LPO produky, resveratrol.}